Patent 7186550 was granted and assigned to Murdoch Childrens Research Institute on March, 2007 by the United States Patent and Trademark Office.
The present invention is directed generally to an isolated nucleic acid molecule encompassing a neocentromere or a functional derivative thereof or a latent, synthetic or hybrid form thereof and its use inter alia in developing a range of eukaryotic artificial chromosomes including mammalian (e.g. human) and non-mammalian an artificial chromosomes. Such artificial chromosomes are useful in a range of genetic therapies.