Patent 7192698 was granted and assigned to Purdue Research Foundation on March, 2007 by the United States Patent and Trademark Office.
Method and kits are provided for the detection and diagnosis of metastatic disease. More particularly, the methods and kits employ compounds that can detect EphA2, a specific epithelial cell tyrosine kinase that is overexpressed in metastatic tumor cells. In one embodiment the compound is an antibody capable of binding to an epitope of EphA2.