Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
April 10, 2007
Patent Application Number
09276868
Date Filed
March 26, 1999
Patent Primary Examiner
Patent abstract
The present invention provides both a method and means for regulating angiogenesis within living cells, tissues, and organs in-situ. The regulation is performed using native PR-39 peptide or one of its shorter-length homologs, for direct interaction with the α7 subunit of such proteasomes as one present in the cytoplasm of viable cells. The result of PR-39 peptide interaction with proteasomes is a decrease in the intracellular degradation of active peptides such as HIF-1α and a consequential stimulation of angiogenesis in-situ.
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