Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Liang Qiao0
Jianzhong Liu0
Wei Shi0
Yujun Huang0
Date of Patent
April 17, 2007
0Patent Application Number
110600340
Date Filed
February 17, 2005
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention involves a papilloma pseudovirus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudovirus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudoviruses (VLPs with plasmids inside). Oral administration of the pseudoviruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudovirus induces stronger immune response than DNA vaccines. Additionally, the pseudovirus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
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