US Patent 7217712 4-Substituted-5-cyano-1H-pyrimidin-6-(thi)ones as GSK-3 inhibitors

Patent 7217712 was granted and assigned to Vertex Pharmaceuticals on May, 2007 by the United States Patent and Trademark Office.

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Current Assignee

Vertex Pharmaceuticals

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

72177120

Patent Inventor Names

Young-Choon Moon0

Date of Patent

May 15, 2007

Patent Application Number

107995070

Date Filed

March 12, 2004

Patent Primary Examiner

‌

Deepak Rao

Patent abstract

The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions comprising compounds of formula I to inhibit GSK-3 activity. The invention further provides methods of utilizing these compounds and pharmaceutical compositions in the treatment and prevention of various GSK-3-mediated disorders, such as diabetes and Alzheimer's disease.

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