Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
May 15, 2007
Patent Application Number
10394388
Date Filed
March 21, 2003
Patent Primary Examiner
Patent abstract
In this application is described a protective DNA vaccines against infection with HFRS- and HPS-associated hantaviruses. The vaccines were constructed by subcloning cDNA representing the medium (M) (encoding the G1 and G2 glycoproteins) into the DNA expression vector pWRG7077. Animals vaccinated with the M construct developed a neutralizing antibody response. Passive transfer experiments show that serum from vaccinated animals, when injected on days 4 or 5 after challenge, protected animals from lethal disease.
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