Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Susan L. Kozak0
David Kabat0
Kristine M. Rose0
Mariana Marin0
Date of Patent
May 22, 2007
0Patent Application Number
108387700
Date Filed
May 3, 2004
0Patent Primary Examiner
Patent abstract
Vif binds to APOBEC3G and induces its rapid degradation, thus eliminating it from cells and preventing its incorporation into HIV-1 virions. Vif contains two domains, one that binds APOBEC3G and another with a conserved SLQ(Y/F)LA motif that mediates APOBEC3G degradation by a proteasome-dependent pathway. Provided herein are methods of exploiting these discoveries to develop compounds useful to inhibit Vif degradation of APOBEC3G, and thereby inhibit viral infection and/or replication.
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