Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jan Van Deursen0
Cheryl A. Conover0
Date of Patent
May 22, 2007
Patent Application Number
10499472
Date Filed
January 3, 2003
Patent Primary Examiner
Patent abstract
The invention provides materials and methods related to a transgenic non-human mammal whose genome comprises a disrupted PAPP-A allele. Methods for making such transgenic non-human mammals, and using them identify and characterize agents that affect conditions related to PAPP-A activity, such as vascular restenosis, atherosclerosis, wound healing, cancer, fibrosis, bone development, fetal development, longevity, and fracture repair, also are provided.
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