The invention relates to a sensor and guide wire assembly (20) for intravascular measurements of physiological variables in a living body, comprising a core wire (21) and a sensor element (22). The sensor and guide wire assembly (20) comprises further a jacket (25; 35; 45) provided with a first opening (26; 36; 46), in which at least a portion of the sensor element (22) is arranged, and a second opening (27; 37; 47), in which a portion of the core wire (21) is arranged, the first opening (26; 36; 46) and the second opening (27; 37; 47) being separated from each other.