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US Patent 7223556 Targeted proteolysis by recruitment to ubiquitin protein ligases

Patent 7223556 was granted and assigned to President and Fellows of Harvard College on May, 2007 by the United States Patent and Trademark Office.

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Patent abstract

The present invention relates to methods and reagents for targeting proteolysis of a polypeptide by cis or trans association with a ubiquitin protein ligase, and further provides methods and reagents for inhibiting the ubiquitination and proteolysis of cellular proteins which are recognized by a ubiquitin protein ligase.

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