Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Anders Hjelholt Pedersen0
Kim Vilbour Andersen0
Per Ola Freskgaard0
Date of Patent
June 5, 2007
0Patent Application Number
110041110
Date Filed
December 3, 2004
0Patent Primary Examiner
Patent abstract
The present invention relates to novel conjugates between polypeptide variants of protein C and a non-polypeptide moiety, such as PEG or sugar moieties. In particular, the present invention provides novel protein C conjugates having an increased resistance to inactivation by e.g. human plasma and α1-antitrypsin. Consequently, such conjugates have an increased in vivo half-life. Preferred examples include protein C conjugates, wherein at least one additional in vivo N-glycosylation site has been introduced. The conjugates of the invention are useful for treating a variety of diseases, including septic shock.
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