Patent 7227016 was granted and assigned to Ionis Pharmaceuticals on June, 2007 by the United States Patent and Trademark Office.
Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.