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US Patent 7235585 Enzyme activated self-immolative n-substituted nitrogen mustard prodrugs

Patent 7235585 was granted and assigned to Cancer Research Technology Limited on June, 2007 by the United States Patent and Trademark Office.

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Patent abstract

This invention pertains to certain enzyme (CPG2) activated self-immolative nitrogen mustard prodrugs, which are useful in enzyme prodrug therapy (EPT), such as ADEPT and GDEPT, for the treatment of proliferative conditions, such as cancer, and which have the following formula:

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