Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Koji Sode0
Date of Patent
July 17, 2007
0Patent Application Number
105177020
Date Filed
June 13, 2003
0Patent Primary Examiner
Patent abstract
Disclosed is a modified glucose dehydrogenase having pyrroloquinoline quinone as a coenzyme, wherein one or more amino acid residues in a region of amino acid 349-377 of water-soluble PQQGDH derived from Acinetobacter calcoaceticus is replaced with other amino acid residues and has an inhibition constant (Ksi) of 200 mM or more. The modified water-soluble PQQGDH of the invention can be utilized for measuring glucose levels in the presence of high concentrations of glucose because of the low substrate inhibition by glucose.
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