A quick-release printhead mounting assembly and thermal printer incorporating same, including a printing component, a printer housing, and, a component retention feature attached to or molded into the printer housing adapted for receiving and releasably fixing the printing component to the housing. The retention feature holds the printhead in a fixed position relative to the housing and, therefore, also relative to the platen of the printer. The printing component is advantageously a printhead, such as a thermal printhead, or the combination of a thermal printhead and a heat sink.