A tablet cassette for a medicine packing machine is disclosed. The tablet cassette for a medicine packing machine includes a cassette for accommodating tablets and having a passage formed at one side of a lower end thereof, a cassette support with which the cassette is detachably coupled on the upper surface of the cassette support and which has an inclined passage communicated with the passage in one side thereof, and a discharge driver provided in the cassette and the cassette support. The discharge driver includes a conic rotating body provided in the cassette and having divisional protrusions on the outer circumference thereof, and a driving motor provided in the cassette support to rotate the rotating body in a forward direction and to rotate the rotating body in a reverse direction when tablets are lodged such that an overload is generated.