Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Merli Valeriano0
Paola Daverio0
Stefano Bianchi0
Date of Patent
August 21, 2007
Patent Application Number
10958072
Date Filed
October 4, 2004
Patent Primary Examiner
Patent abstract
Processes for separation of enantiomers of clopidogrel, and converting one enantiomer of clopidogrel to another enantiomer of clopidogrel are provided. The enantiomers are separated by crystallizing the (S) enantiomer as camphor sulfonate salt from a hydrocarbon, or a mixture of a hydrocarbon and a co-solvent, preferably DMF:toluene. The (R) enantiomer is then racemized and recycled by reaction with a catalytic amount of a base, preferably with t-butoxide.
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