Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Shigeru Sassa0
Bala Krishna Kolli0
Daniel A. Peterson0
Hiroya Ito0
Jerome F. Sah0
Kwang-Poo Chang0
Date of Patent
August 28, 2007
0Patent Application Number
102938670
Date Filed
November 12, 2002
0Patent Primary Examiner
Patent abstract
Methods for delivering potentially therapeutic or prophylactic protein and peptide agents to mammalian cells are provided. The agents are delivered by mutant trypanosomatid protozoa that have been genetically manipulated to code for such protein or peptide agents. The mutant protozoa additionally lack certain enzymes within the heme biosynthetic pathway, making the mutants susceptible to porphyria and eventual lysis.
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