Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Steven A Signs0
Steven P Schmidt0
Christopher J Woolverton0
Gary D Niehaus0
Kathleen J Doane0
Oleg D Lavrentovich0
Date of Patent
September 11, 2007
0Patent Application Number
101336100
Date Filed
April 26, 2002
0Patent Primary Examiner
Patent abstract
A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an enzyme, whereby the enzyme is separated from its substrate by an receptor; and a receptor engineered to inhibit the active of site of an enzyme only in the absence of a ligand. Also provided are methods for the automatic detection of ligands.
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