Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Hellmut Eckstein0
Johann-Peter Thalhofer0
Michael Ratka0
Rainer Muller0
Stephan Glaser0
Stephanie Ronning0
Bernhard Rexer0
Claudia Giessel0
...
Date of Patent
October 2, 2007
0Patent Application Number
104705080
Date Filed
February 1, 2002
0Patent Primary Examiner
Patent abstract
The present invention concerns a method for producing recombinant trypsin from porcine pancreas in Pichia pastoris which is soluble and secreted into the culture medium, whereby expression at pH 3.0-4.0 substantially prevents activation of trypsinogen to β-trypsin and autolysis of β-trypsin by α-trypsin into ε-trypsin and from there into inactive peptides.
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