Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Gregory Cope0
Rati Verma0
Raymond J. Deshaies0
Xavier I. Ambroggio0
Date of Patent
October 9, 2007
0Patent Application Number
103405780
Date Filed
January 9, 2003
0Patent Primary Examiner
Patent abstract
Methods for identifying agents that can increase or decrease the isopeptidase activity of a COP9 signalsome (CSN) are provided, as are agent identified using such screening assays. In addition, methods of ameliorating a pathologic condition such as a cancer or an autoimmune disease in a subject by modulating the CSN isopeptidase activity are provided, as are medicaments useful for treating a subject having such a condition.
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