Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
October 9, 2007
0Patent Application Number
112933530
Date Filed
December 1, 2005
0Patent Primary Examiner
Patent abstract
The present invention provides a process for the preparation of pimecrolimus from ascomycin in which ascomycin is reacted with a conversion reagent that converts ascomycin to its activated derivative at C-32. The activated ascomycin is then reacted with chloride ion. The process of the invention requires fewer process steps than prior art processes, and does not require the protection of the ascomycin C-24 hydroxyl group or the purification of the activated ascomycin derivative.
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