US Patent 7282493 Analogs of benzoquinone-containing ansamycins and methods of use thereof

Patent 7282493 was granted and assigned to Infinity Pharmaceuticals on October, 2007 by the United States Patent and Trademark Office.

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Patent

Patent attributes

Current Assignee

Infinity Pharmaceuticals

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

72824930

Patent Inventor Names

Roger H. Pak0

Yun Gao0

Asimina T. Georges Evangelinos0

James L. Wright0

James R. Porter0

Julian Adams0

Louis Grenier0

Date of Patent

October 16, 2007

Patent Application Number

110220570

Date Filed

December 23, 2004

Patent Primary Examiner

‌

Bruck Kifle

Patent abstract

The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

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