Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
November 6, 2007
0Patent Application Number
100472530
Date Filed
January 14, 2002
0Patent Primary Examiner
Patent abstract
The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.
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