Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Bert Vogelstein0
Nicholas Nicolaides0
Kenneth W. Kinzler0
Date of Patent
November 20, 2007
Patent Application Number
09558149
Date Filed
April 26, 2000
Patent Primary Examiner
Patent abstract
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation.
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