US Patent 7300749 Molecules of the pyrin domain protein family and uses thereof

Patent 7300749 was granted and assigned to Millennium Pharmaceuticals on November, 2007 by the United States Patent and Trademark Office.

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Patent

Patent attributes

Current Assignee

Millennium Pharmaceuticals

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7300749

Date of Patent

November 27, 2007

Patent Application Number

10127516

Date Filed

April 22, 2002

Patent Primary Examiner

‌

Karen A. Canella

Patent abstract

Diagnostic, screening and therapeutic methods utilizing NBS-1 and PYRIN-1 are disclosed. The methods take advantage of the interactions between NBS-1 or PYRIN-1 and various proteins involved in apoptotic and inflammatory signaling pathways. Also disclosed are methods for identifying modulators of ASC and NF-κB.

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