Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
November 27, 2007
Patent Application Number
11136887
Date Filed
May 25, 2005
Patent Primary Examiner
Patent abstract
The present invention relates to a mutated pyruvate carboxylase gene from Corynebacterium. The mutant pyruvate carboxylase gene encodes a pyruvate carboxylase enzyme which is resistant to feedback inhibition from aspartic acid. The present invention also relates to a method of replacing the wild-type pyruvate carboxylase gene in Corynebacterium with this feedback-resistant pyruvate carboxylase gene. The present invention further relates to methods of the production of amino acids, preferably lysine, comprising the use of this mutant pyruvate carboxylase enzyme in microorganisms.
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