Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Merry Jo Velasquez0
Malayannan Subramaniam0
Nalini M. Rajamannan0
Thomas C. Spelsberg0
Date of Patent
December 4, 2007
0Patent Application Number
109444540
Date Filed
September 17, 2004
0Patent Primary Examiner
Patent abstract
Materials and methods related to a transgenic non-human animal (e.g., a transgenic non-human mammal) whose genome comprises a disrupted TIEG allele are provided. Methods for making such transgenic non-human animals, and using them to identify and characterize agents that affect conditions related to TIEG activity, such as cardiac hypertrophy and bone formation also are provided. In addition, materials and methods related to the treatment of hypertrophic cardiomyopathy are provided.
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