The present invention concerns multi-user detection method of symbols transmitted over a downlink of a multi-carrier code division multiple access telecommunication system, the symbols for a user of the system being spread with a signature over a plurality of carriers, the signal received by a user being decomposed into a plurality of frequency components and said frequency components being despread with said signature. Prior to despreading, said frequency components are equalized by multiplying each of said components with a coefficient, said coefficients taking into account an interference level, after despreading, between the symbols for said user and the symbols for the other users of the system.