US Patent 7329681 Inhibitors of IMPDH enzyme

Patent 7329681 was granted and assigned to Vertex Pharmaceuticals on February, 2008 by the United States Patent and Trademark Office.

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US Patent 12076315 Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof

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US Patent 12012383 Compositions and methods for inhibiting dihydroorotate dehydrogenase

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Patent Inventor Names

Catharine A Frank0

David M Armistead0

Guy W Bemis0

Jeffrey O Saunders0

Michael C Badia0

Perry M Novak0

Randy S Bethiel0

Steven M Ronkin0

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Patent abstract

The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

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