A digital-to-analog (D/A) conversion device including a data-latch unit, a D/A conversion unit and a gain amplifier is provided. Wherein, the amplitude of the supply voltages for the reference voltage of the D/A conversion unit is not greater than that of the data-latch unit so that the switches in a switch control unit of the D/A conversion unit can be fully turned on or off without using level-shift units. The output amplifier must have a gain to amplify the output signal of the D/A conversion unit to an expected voltage range.