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US Patent 7332168 Composition for the elimination of autoreactive B-cells

Patent 7332168 was granted and assigned to Micromet on February, 2008 by the United States Patent and Trademark Office.

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Current Assignee
Micromet
Micromet
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
73321680
Patent Inventor Names
Marcel Zocher0
Patrick Bäeuerle0
Torsten Dreier0
Date of Patent
February 19, 2008
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Patent Application Number
103625910
Date Filed
August 22, 2001
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Patent Citations Received
‌
US Patent 11866508 Anti-mesothelin binding proteins
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Patent Primary Examiner
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Christina Chan
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Patent abstract

The present invention relates to a composition for the selective elimination of autoreactive B-cells comprising at least one (poly)peptide construct consisting of at least two domains wherein one of said domains comprises an autoreactive antigen or (a) fragments(s) thereof specifically recognized by the Ig receptors of said autoreactive B-cells and wherein one of said domains comprises an effector molecule capable of interacting with and/or of activating NK-cells, T-cells, macrophages, monocytes and/or granulocytes and/or capable of activating the complement system.

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