A system and method for securing a fuel injector in an internal combustion engine include a clamp for securing adjacent injectors to a cylinder head. The clamp includes a central portion with a hole for receiving a fastener to secure the clamp to the cylinder head, and a pair of symmetrical crescent-shaped clamping forks forming a U-shaped opening to facilitate lateral sliding engagement with diametrically opposed flatted portions of corresponding fuel injectors. Each arm includes an arcuate pad that engages a corresponding shoulder of the fuel injector to provide an axial clamping force to the fuel injector. The distance between the distal ends of one fork and the semicircular portion of the opposite fork is selected to allow lateral sliding disengagement of the clamp from one of the adjacent injectors without rotation or removal of the other injector to facilitate servicing of individual injectors.