Patent 7368549 was granted and assigned to EPOCH BIOSCIENCES, INC. on May, 2008 by the United States Patent and Trademark Office.
Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.