Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Byung Hwan Kim0
Seon Yi Jeong0
Yang Rai Cho0
Young Ji Shim0
Eon Cheol Koo0
Date of Patent
May 13, 2008
0Patent Application Number
117847900
Date Filed
April 10, 2007
0Patent Primary Examiner
Patent abstract
Provided is a novel preparation method of (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid represented by the following formula (1), a key intermediate of cilastatin used as a supplement to imipenem. The novel preparation method of the invention produces a pure (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid, a key intermediate of cilastatin, by selective hydrolysis of E isomers.
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