The tamper-evident closure is provided for a syringe with a Luer connection or a Luer lock connection, wherein at least the connection end consists of plastic. A cap which is connected to the syringe via at least one frangible web. The cap and the frangible web together with a fixation component are formed as one piece as a plastic injection molded part and are connected to the connection end of the syringe by way of welding.