US Patent 7375217 Analogs of benzoquinone-containing ansamycins and methods of use thereof

Patent 7375217 was granted and assigned to Infinity Pharmaceuticals on May, 2008 by the United States Patent and Trademark Office.

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Patent

Patent attributes

Current Assignee

Infinity Pharmaceuticals

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

73752171

Patent Inventor Names

James R. Porter1

Louis Grenier1

Julian Adams1

Yun Gao1

Roger H. Pak1

Asimina T. Georges Evangelinos1

James L. Wright1

Date of Patent

May 20, 2008

Patent Application Number

111081651

Date Filed

April 14, 2005

Patent Primary Examiner

‌

Bruck Kifle

Patent abstract

The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

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