Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Tze Chein Wun0
Date of Patent
May 27, 2008
0Patent Application Number
105169080
Date Filed
June 4, 2003
0Patent Primary Examiner
Patent abstract
Novel recombinant anticoagulation proteins, methods of their use and methods of their production are described. In particular, recombinant fusions of annexin V (ANV) and Kunitz protease inhibitors (KPI) that possess potent anticoagulant activity are provided. The fusions, abbreviated ANV:KPI, utilize ANV having high affinity for phosphatidyl-L-serine with various KPI's to target serine proteases in membrane-associated coagulation complexes in the blood coagulation cascade. ANV:KPIs are potentially useful antithrombotic drugs permitting localized passivation of thrombogenic vessel walls and associated thrombi.
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