An ergonomic computer mouse has an arcuate top surface, a front end, a rear end, and left and right sidewalls. The top surface has a circular side view profile that extends from the front end to the rear end and is contiguous with finger buttons on the mouse. The surface of the left or thumb sidewall is uniquely contoured for the left side of the user's hand and thumb. A large thumb ball support protrudes from the rear half of the left sidewall at an incline. The thumb ball support and rear end have a circular shape when viewed from above. The left sidewall also has a concave thumb channel for the thumb of the user. An elongated thumb button is located above the thumb channel in order to avoid accidental thumb button actuations. The mouse also has a pair of finger buttons and a scroll tab at the front of its top surface. Each of these features on the mouse are ergonomically designed to conform to the natural shapes and positions of the user's hand during use.