US Patent 7399836 Method of manufacturing a carrier having immobilized antibodies

Carrier and method of its manufacture having immobilized antigens or antibodies, including a carrier having a surface, in which at least the surface of the carrier is formed of a calcium phosphate based compound; antiligands provided on and surrounding the surface of the carrier; a blocking layer formed of a protein having low interaction with antigens or antibodies, the blocking layer being formed on a portion of the surface of the carrier where the antiligands are not provided; and antigens or antibodies each having a portion that is irrelevant to the antigen-antibody reaction on which a ligand is provided, the antigens or antibodies being immobilized to the surface of the carrier through the bonding between the ligands and the antiligands with the blocking layer effectively preventing antigens or antibodies from being directly absorbed to the surface without bonding between the ligands and the antiligands.