Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
August 5, 2008
Patent Application Number
11670830
Date Filed
February 2, 2007
Patent Primary Examiner
Patent abstract
The invention provides methods for identifying peptide epitopes that activate CD4+ T cells involved in the pathogenesis of diseases, e.g., autoimmune diseases, susceptibility to which is determined by expression of particular class II MHC genes. The invention includes peptides derived from the IA-2 polypeptide by such a method, altered peptide ligands, and methods of therapy involving the use of altered peptide ligands.
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