Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Thomas R. Spitzer0
Megan Sykes0
Date of Patent
August 5, 2008
0Patent Application Number
103743020
Date Filed
February 25, 2003
0Patent Primary Examiner
Patent abstract
The inventors have discovered that hematologic disorders, e.g., both neoplastic (hematologic cancers) and non-neoplastic conditions, can be treated by the induction of mixed chimerism using myeloreductive, but not myeloablative, conditioning. Methods of the invention reduce GVHD, especially GVHD associated with mismatched allogeneic or xenogeneic donor tissue, yet provide, for example, significant graft-versus-leukemia (GVL) effect and the like.
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