Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Geraldine F Dellinger0
Douglas J Dellinger0
Marvin H Caruthers0
Agnieszka B. Sierzchala0
Date of Patent
August 26, 2008
0Patent Application Number
106520540
Date Filed
August 30, 2003
0Patent Citations Received
0
Patent Primary Examiner
Patent abstract
Methods of forming an internucleotide bond are disclosed. Such methods find use in synthesis of polynucleotides. The method involves contacting a functionalized support with a precursor having an exocyclic amine triaryl methyl protecting group under conditions and for a time sufficient to result in internucleotide bond formation. The functionalized support includes a solid support, a triaryl methyl linker group, and a nucleoside moiety having a reactive site hydroxyl, the nucleoside moiety attached to the solid support via the triaryl methyl linker group. In particular embodiments, the precursor has the structure:
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