Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Yasushi Imai0
Tetsuya Kubota0
Toshimasa Yamauchi0
Yasuo Terauchi0
Naoto Kubota0
Ryozo Nagai0
Takashi Kadowaki0
Tetsuo Noda0
Date of Patent
September 2, 2008
0Patent Application Number
105147150
Date Filed
May 26, 2003
0Patent Primary Examiner
Patent abstract
A scavenger receptor A expression down-regulator and a drug for preventing or treating arteriosclerosis which contain, as the active ingredient, a C-terminal globular domain of adiponectin, adiponectin, or a gene encoding the domain or adiponectin. According to the present invention, there is provided a preventive or therapeutic agent capable of directly preventing intimal thickening, which constitutes an essential feature of arteriosclerosis. This effect can be attained through arresting the onset and development of arteriosclerosis by reducing the expression level of scavenger receptor A in arterial walls and preventing lipid buildup in macrophages.
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