Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jonathan F. Smith0
Kurt I. Kamrud0
Sergey A. Dryga0
Ian J. Caley0
Jonathan O. Rayner0
Date of Patent
September 16, 2008
0Patent Application Number
113769010
Date Filed
March 16, 2006
0Patent Citations Received
0
...
Patent Primary Examiner
Patent abstract
The present invention provides compositions useful in and methods for producing populations of infectious, replication-defective alphavirus replicon particles that contain no replication competent alphavirus particles, as determined by passage on cells in culture. The compositions include helper and replicon nucleic acid molecules that can further reduce the predicted frequency for formation of replication-competent virus and can optimize manufacturing strategies and costs.
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