Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Bent Karsten Jakobsen0
Meir Glick0
Date of Patent
September 16, 2008
0Patent Application Number
104795090
Date Filed
June 14, 2002
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides modified CD8 molecules whose binding to MHC is enhanced compared to wild-type CD8, wherein Ser53 of at least one CD8α chain thereof is mutated to another amino acid. It also provides nucleic acids encoding such molecules and methods of using such molecules and nucleic acids in immunosuppressive therapy, in particular as inhibitors of cytotoxic T cell responses.
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