A semi-automatic medicine packaging machine includes a medication feed outlet that feeds and discharges medications into a hopper, a sealing unit that seals medications in the hopper by medication envelope(s) on which instruction labels are printed by a printing unit, a button operation unit that inputs a user's operation into the controller, a manual dispensing tray, an automatic supply unit including a plurality of tablet cassettes, and a user information input unit that inputs user information into a controller that controls the overall operation of the machine and includes a user authentication unit for authenticating a user.