Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Yeny Torres Ruiz0
Giselle Pentón Roll0
Iraldo Bello Rivero0
Pedro López Saura0
Elizabeth Blanco Garcés0
Date of Patent
September 30, 2008
0Patent Application Number
105139310
Date Filed
May 8, 2003
0Patent Primary Examiner
Patent abstract
A recombinant chimeric antagonist formed by a 60 amino acid fragment of the N-terminal region of human interleukin 2 (IL-2) fused to the N-terminal of the extracellular region of the alpha subunit of the gamma IFN (IFN γ) receptor. In vitro this protein has a T cell growth stimulating activity, it inhibits the growth stimulating activity of IL-2 in T cells, it inhibits the induction of HLA-DR by IFN γ and it inhibits the antiproliferative activity of γ IFN. This invention can be applied in the field of medicine for the treatment of several pathologies such as autoimmune diseases, graft rejections, chronic inflammations, sepsis, ischemia and reperfusion syndrome and atherosclerosis.
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