A door and frame combination for an air handling unit consists of a frame, a hinged door with a hollow core filled with insulating material, and a gasket having a flexible gasket wall with anti-roll extensions. The gasket may have a friction-reducing material on its surface to assist in preventing roll-over by the closing door. Optional thermal pockets in the door and frame are filled with high-density polyurethane to provide further protection against air leakage.