Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ajith A. Welihinda0
Randal J. Kaufman0
Witoon Tirasphon0
Date of Patent
October 21, 2008
0Patent Application Number
108919730
Date Filed
July 14, 2004
0Patent Primary Examiner
Patent abstract
A novel polynucleotide encoding a mammalian bifunctional protein kinase\endoribonuclease referred to herein as hIre1p, is provided. hIre1p is expressed in the endoplasmic reticulum (ER) and upregulates the transcription of genes encoding ER protein chaperones, such as, but not limited to, glucose-related proteins (GRP's). Therapeutic, diagnostic and research methods employing the polynucleotide and protein are also provided.
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